The Bioinformatics and Human Electrophysiology Lab (BiHELab) focuses on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments. BiHELab’s goal is to help bridge the translational gap from data to models and from models to drug discovery and personalized therapy by fostering collaborations and developing original quantitative approaches to biological and clinical problems. BiHELab with Johns Hopkins Medicine is leading the Hellenic Initiative Against Alzheimer’s Disease (HIAAD). The mission of HIAAD is to implement an evolved national strategic plan for Alzheimer’s Disease and related disorders (ADRD) in Greece built around Precision Medicine as a model for other nations, engaging a broad coalition of Greek stakeholders worldwide, articulating a research agenda, and aggressively implementing given the urgency of the matter. BiHELab organizes every two years the worldwide congress on “Genetics, Geriatrics and Neurodegenerative Diseases Research” since 2014. GENEDIS focuses on timely subjects, as we witness revolutionary development in scientific research of drug targets, of novel biomarkers, of the new imaging techniques, of the novel protocols for early diagnosis of neurodegenerative diseases, and of several other scientific advances within the frame of personalized medicine. BiHELab staff is currently working on several research and development projects dealing with clinical trial platforms, decision support systems, computational and digital biomarkers, neuroeducation, medical imaging, atomic force microscopy for protein folding and others.